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Home Covid-19 News

Russia’s Sputnik V vaccine is 91.6% effective against symptomatic Covid-19, interim trial results suggest

by The Lagos Today
February 2, 2021
in Covid-19 News, World News
4 min read
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Russia’s Sputnik V vaccine is 91.6% effective against symptomatic Covid-19, interim trial results suggest
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After criticism last year for an early rollout, Russia’s Sputnik V vaccine is 91.6% effective against symptomatic Covid-19 and 100% effective against severe and moderate disease, according to an interim analysis of the vaccine’s Phase 3 trial results.

The preliminary findings were published in The Lancet on Tuesday and are based on data gathered from 19,866 participants, of which around three-quarters (14,964) received two doses of the vaccine and a quarter (4,902) were given a placebo.

Sixteen cases of symptomatic Covid-19 were confirmed in the vaccine group 21 days after participants received the first vaccine dose. Sixty two cases were found in the placebo group — equating to an efficacy of 91.6%.

The trial included 2,144 people over the age of 60 and a sub-analysis conducted on this group revealed the vaccine was well tolerated and had a similar efficacy of 91.8%.

The team also analyzed the efficacy of the vaccine against severe and moderate Covid-19 disease and 21 days after the first dose no severe or moderate cases were reported in the vaccinated group, while 20 were reported in the placebo group.

Serious adverse events associated with vaccination were also rare — less than 0.2% in people who received the vaccine. The majority of side-effects that were reported were mild side, such as pain at the injection site, flu like symptoms and low energy levels, according to the study.

The analysis includes only symptomatic cases of Covid-19, however, and the authors note more research is needed to understand the vaccine’s efficacy against asymptomatic Covid-19, transmission and how long protection may last.

The majority of participants in the trial were also white so further research is needed to confirm the results across other ethic groups. The trial is also ongoing and is aiming to include a total of 40,000 participants.

Dr. Inna V Dolzhikova, co-lead author of the study, said the analysis suggested the vaccine had “high efficacy, immunogenicity, and a good tolerability profile in participants aged 18 years or older.”

Dolzhikova works at Russia’s Gamaleya National Research Centre for Epidemiology and Microbiology, which developed the vaccine.

The people in the trial were given PCR Covid-19 tests when they received the second shot. They took a further test if they reported symptoms of respiratory infection.

The Sputnik V vaccine is a two-dose adenoviral vector vaccine using two different adenoviruses for each dose, with doses administered 21 days apart. With this type of vaccine, an adenovirus is altered so that it can deliver a piece of genetic material from the virus that causes Covid-19 into the body and get cells to express the spike induce found on the virus and induce an immune response. It’s an approach similar to the vaccines developed by AstraZeneca and Johnson & Johnson.

The authors say that using a different adenovirus vector for the booster vaccination may help create a more powerful immune response.

One advantage of adenoviral vaccines is that they do not need to be stored and transported in extremely cold temperatures, scientists say. Sputnik V only needs to be refrigerated and costs $10 per dose, according to Russian Direct Investment Fund, which funded vaccine production and is responsible for selling it globally.

“This is a useful addition to the published data on Covid-19 vaccine effectiveness,” Dr. Julian Tang, clinical virologist at the University of Leicester.

But he highlighted that “median follow up was 48 days from the first dose, so the study cannot assess the full duration of protection.”

The vaccine’s production has been funded by the Russian Direct Investment Fund (RDIF), which is also responsible for selling it globally.

The vaccine is already approved in Russia, Belarus, Serbia, Argentina, Bolivia, Algeria, Venezuela, Paraguay, Turkmenistan, Hungary, UAE, Iran, Guinea, Tunisia, Armenia and the Palestinian territories. Sputnik V has so far been administered to more than 2 million people worldwide.

Russia drew criticism from scientific circles last year when it approved Sputnik V for public use in August — before the crucial Phase 3 trials had been completed.

“Despite the earlier misgivings about the way this Russian Sputnik V vaccine was rolled out more widely — ahead of sufficient Phase 3 trial data — this approach has been justified to some extent now,” Tang said.

“The vaccine trial results are coming thick and fast as high infection rates in areas where Phase 3 clinical trials provide increasing amounts of data that together encourages us to believe that vaccines will soon be able to drive down the human cost of Covid-19,” added Alexander Edwards, associate professor in Biomedical Technology at the Reading School of Pharmacy, University of Reading.

“Manufacturing may remain a bottleneck for months to come, so the more vaccines available, the better for global health,” he said.

CNN

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